Dietary protein effects in elderly women: musculoskeletal, renal, cardiovascular and body composition endpoints.

The effects of dietary protein on bone structure and metabolism have been controversial, with evidence for and against beneficial effects. Because no long-term randomized, controlled studies have been performed at this point in time, a two-year study of protein supplementation in 219 healthy ambulant women aged 70 to 80 years was undertaken. Participants were randomized to either a high-protein drink containing 30 g of whey protein (n = 109) or a placebo drink identical in energy content, appearance, and taste containing 2.1 g of protein (n = 110). Both drinks provided 600 mg of calcium. Dual-energy X-ray absorptiometric (DXA) hip areal bone mineral density (aBMD), 24-hour urinary calcium excretion, and serum insulin-like growth factor 1 (IGF-1) were measured at baseline and at 1 and 2 years. Quantitative computed tomographic (QCT) hip volumetric bone mineral density (vBMD) and a femoral neck engineering strength analysis were undertaken at baseline and at 2 years.

PIMES Protocol

PIMES Data Dictionary – Outlines the types of data available as well as information about it’s collection

Associated publications:

The effects of a two-year randomized, controlled trial of whey protein supplementation on bone structure, IGF-1, and urinary calcium excretion in older postmenopausal women.

Long-term effects of a protein-enriched diet on blood pressure in older women.

Two-Year Whey Protein Supplementation Did Not Enhance Muscle Mass and Physical Function in Well-Nourished Healthy Older Postmenopausal Women.

Consumption of a whey protein-enriched diet may prevent hepatic steatosis associated with weight gain in elderly women.

A 15-year longitudinal study investigating the role of environmental, anatomical, physiological, metabolic and genetic factors on health outcomes in older women.

The CAIFOS/CARES/CAREERS cohort belongs to the Bone and Vascular Research Group (BVRG) at the University of Western Australia and is collectively referred to as the Longitudinal Study of Ageing Women (LSAW).

Calcium Intake Fracture Outcome Study (CAIFOS) 1998-2003

1500 women were originally recruited for the Calcium Intake Fracture Outcome Study (CAIFOS), a five-year population-based study of women aged >70 years to determine the efficacy of calcium supplementation (1200mg/d) in fracture prevention in 1998.

CAIFOS Age Related Extension Study (CARES) 2003-2008

Of the 1275 study subjects who remained active at the end of the CAIFOS study (2003), 1136 subsequently enrolled in the CARES study, a five-year NHMRC supported extension of the CAIFOS study to collect further information regarding factors that influence osteoporosis and other diseases.

CAIFOS Age Related Extension Extension Study (CAREES) 2008-2013

In February 2008, 963 (85%) of the CARES cohort (64% of the CAIFOS cohort) were still active in the NHMRC funded CAREES cohort study of aging (Project number 572604) which completed in 2013.

Hospital Morbidity Data Management System

All participants have linked hospital morbidity data through the West Australian Hosptial Morbidity Data Management System.

Biological samples

Biological samples (blood and urine) were also collected at multiple time points and will be available for future analysis, subject to ethical compliance. This cohort represents a valuable opportunity for cost effective future research. Additional information about the available data can be found in the LSAW Data Dictionary’s.

Ethics

In accordance with Australian Code for the Responsible Conduct of research and Research Data Management Policies from the collaborating universities, this effort would promote the availability and use of the existing data to the research community.

To achieve successful healthy ageing for all Australians this collaboration will focus on maximising the utility of a large population-based epidemiological study of ageing, to determine the influence of nutritional and lifestyle determinants on health impacts and death in women.

The research findings will be disseminated and translated to the community through a variety of activities including a website

The website will:

• • Create a sustainable platform for continued use and monitored access to a valuable epidemiological resource to achieve research into successful healthy ageing.

Provide a cost effective data source for future Australian and International higher degree student/researchers from Curtin University, ECU and UWA, as well as researchers from other institutions to increase outputs, collaborations and grant success in those

Meet the researchers of the Perth Longitudinal Study of Ageing Women (PLSAW) team

Click the links below to view the PLSAW protocols:

Longitudinal Study of Ageing Women

• • CAIFOS and CalD Protocol (1998-2003)

• • CARES Protocol (2003-2008)

• • CAREES Protocol (2008-2013)

Other PLSAW studies

• • Protein Intake Metabolic Effects Study Protocol

• • Bone and Balance Study Protocol

Protein Intake Metabolic Effects Study (PIMES)

This study was supported by the Australian National Health Medical Research Council (Project Grant 458625) and the University of Western Australia Research Grants Scheme.

Longitidunal Study of Ageing Women (LSAW)

The original research was supported by Healthway Health Promotion Foundation of Western Australia Grant 6018 1998 2000 and National Health and Medical Research Council of Australia Project Grant 254627 and 303169. Additional supporting grants for the main and secondary projects have been received since 1998 and are outlined here.

This website (Site) is owned and operated by the Longitudinal Study of Ageing Women (LSAW) Consortium (Consortium).

By using or accessing this Site you are agreeing to the terms, conditions and disclaimer information below and elsewhere on the site and decisions made by the Consortium.

While we are very supportive of the use of the participant specific data we collected over 15 years, it is essential that all users adhere to the ethical and legal requirements of our Universities and the Health Dept of Western Australia. This information is to be found as part of the registration process under the request informaiton button.

During the application process you will be asked to provide a protocol to allow us to advise if this project has been undertaken before and to allow us to comment on the viability of the protocol. At a later stage you will also have to provide proof of local ethics approval and submit an application to the Department of Health for the use of their linkage data. Because we have no source of income to support this web site and in particular the data managers salary we will request a cash payment. If a memeber of the LSAW managment committee is interested in the application they may be prepared to assist in data managment, analysis and publication. As such they would have to be acknowledged as a coauthour according to the Journal publication policy.

While the Consortium has used its best endeavours to ensure that all Content including information, text, resources, images and graphics contained in and accessed through the Site is correct, accurate, reliable and current at the time of publication, errors, omissions and defects may occur. Under these circumstances the Consortium will not accept liability for direct, indirect, incidental, special and/or consequential damages, in whole or in part, resulting from your use or reliance upon the Content of the website.

LSAW University CRICOS Codes

UWA CRICOS IPC: 00126G

ECU CRICOS IPC: 00279B

Curtin CRICOS IPC: 00301J